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общ. lose mind (Andrey Truhachev); be out of one's wits; lose one's mind; lose one's reason; lose one's senses; dement; take leave of one's senses; lose sanity; take leave of senses (Anglophile); go daft; lose reason; be out of senses (Andrey Truhachev); be out of mind (Andrey Truhachev); unravel (Toward the end of his life Morphy unraveled. joyand)
идиом. be off beam (VLZ_58)
Макаров. get mad; go mad
перен. come undone (Her mind has come undone, I fear. Andrey Truhachev)
психиатр. become of unsound mind (igisheva)
разг. go cuckoo (VLZ_58)
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идиом. fall into pieces (elkaletom)