уму непостижимо(I just can't wrap my head around how he managed to get himself into this mess! Просто уму непостижимо как он сумел так вляпаться! russoturisto)
перевернуть с ног на голову(turn (something) on its head • I'm afraid we've turned the original mission statement on its head – this is the opposite of what we stand forvogeler)
кардинально изменить что-либо(to change something completely: I really hope that doctors and nurses can pull together and turn the system on its head. Bullfinch)