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6.11.2013 20:40:56 abbr. med. Bondy B. Pharmacogenomics in depression and antidepressants. Dialogues Clin Neurosci. 2005 September 73: 223–230. Current concepts: signal transduction pathways, neuronal plasticity, ami stress response Our present knowledge about the pathophysiological basis of depression and the mechanisms of psychotropic drug action has increased during the last few years. There has therefore been some shift in emphasis from the focus on metabolizing enzymes, neurotransmitter receptors, and transporters toward long4asting adaptive processes, which are related to alterations in signal transduction pathways and mechanisms involving neuronal plasticity, or result from a response to environmental stressors Figure 2.

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