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Subject: TCA pharma. Пожалуйста, помогите перевести следующую аббревиатуру: TCA (описывается аторвастатин кальция)This molecule can also be formed during the TCA formation step (Paal-Knorr reaction) by the reaction of Cyclopentyl amine and TCA.
Observed Range in TCA:
Specification of NMT 0.1% area at TCA.
Observed Range in TCA:
The tetraolamide precursor PF 4735119 will be controlled at 0.1% area at the TCA stage.
The carbon skeleton is generated during the condensation of Cyclopentyl amine with the corresponding desfluoro diketone contaminant (PD 132410) during TCA formation.
PD 138703-38A is formed during drug substance processing from the corresponding desfluoro TCA derivative.
Observed Range in TCA:
PD 138723-38A is formed during drug substance processing from the corresponding difluoro TCA derivative.
Observed Range in TCA:
The carbon skeleton is generated during the condensation of Cyclopentyl amine with the corresponding metafluoro Diketone contaminant (PD 157556) during TCA formation.
PD 157835-38A is formed during drug substance processing from the corresponding metafluoro TCA derivative.
Observed Range in TCA:
Formed during the drug substance step from the corresponding 3S, 5R TCA derivative.
Observed Range in TCA:
Formed during the drug substance step from the corresponding 3S, 5S TCA derivative.
Observed Range in TCA:
Starting material for TCA step.
Observed Range in TCA:
This impurity is controlled at the TCA stage of the process with a specification of 0.7% area.
It has been demonstrated in the laboratory that TCA containing up to 1.1 area% Diketone PD 132411 processes forward to drug substance using the proposed Cyclopentyl Atorvastatin drug substance manufacturing process without an adverse impact on the quality of the resultant isolated drug substance.
Observed Range in TCA:
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