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 Еленаstar

link 18.10.2012 20:03 
Subject: selective antibody pressure gen.
Пожалуйста, помогите перевести: == selective antibody pressure== в предложении:The invention also relates to a method of manufacturing marker vaccines for prevention of
classical swine fever using selective antibody pressure.
В описании дается пояснение:
The term antibody pressure or selective antibody pressure in terms of the present invention relates to the application of antibodies during cell culture, preferably over multiple passages, that are directed to one or more specific epitopes of the virus. Such antibodies can be any kind of antibody known in the art, either mono or polyclonal, or may be contained in serum from animals treated with a peptide of interest, for example the target epitope. Such antibodies are often termed neutralising antibodies. Under the selection pressure of providing neutralising antibodies, viruses, which undergo mutation in the epitope to which the antibodies bind (in this case, the TAV-epitope) are selected due to their growth advantage, as the antibodies no longer bind to said epitope and therefore no longer provide a limiting or neutralising effect, whereby the unchanged wild type viruses are neutralised by the antibodies are subsequently selectively disadvantaged in culture.

Давление селективных антител (?),

Спасибо большое.

 rendezvoir

link 18.10.2012 20:09 
избирательная (селективная) блокада антителами
Диссертация на тему «Влияние блокады α-адренорецепторов ...
www.dissercat.com › ... › Физиология -
Провести сравнительный анализ влияния селективной блокады ... параметров вариационной пульсограммы сердца крыс при избирательной блокаде ...... Characterization of antibodies against the beta 1-adrenoceptor with positive ...

 

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