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Subject: (prepulse ingibition)PPI-disruptive пожалуйста подскажите как переводится? pharm. в тексте:The D1-like agonist R-6-Br-APB decreased PPI in outbred Sprague-Dawley rats . In line with reports in rats where only relatively high doses of a D1 agonist disrupted PPI , R-6-Br-APB was less potent (approximately 125-fold) and less effective than quinelorane in reducing PPI in Sprague-Dawley rats. Moreover, Sprague-Dawley rats were significantly less sensitive to the PPI-disruptive effects of R-6-Br-APB than were Swiss-Webster, 129X1/SvJ, and C57BL/6J mice . Similar to previous reports in mice , R-6-Br-APB decreased PPI in outbred Swiss-Webster mice and inbred 129X1/SvJ and C57BL/6J mice.In contrast, R-6-Br-APB had no significant PPI in the inbred DBA/2J mice .Of the mice tested here, C57BL/6J mice were the most sensitive, and 129X1/SvJ and Swiss-Webster mice were approximately equally sensitive to the PPI-disruptive effects of R-6-Br-APB (see Table 2). In addition to its effects on PPI, R-6-Br-APB also reduced acoustic startle amplitude in Swiss-Webster and C57BL/6J mice .There was no effect of drug treatment on startle amplitude in the Sprague-Dawley rats or 129X1/SvJ and DBA/2J mice . |
| predpulsnoe ingibirovanie proizvodiachee razrushayshii efekt |
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