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Subject: more discriminating charge biol. it was examined to determine if pI (and/or charge) and hydrophobicity were complementary to each other in defining faster versus normal clearance. Also explored was whether charge at a certain pH would be more discriminating with respect to clearance values (antibody clearance involves neonatal Fc receptor salvation through the endosomal environment that has low pH, pH 5 – 6 (where Fc is a C-terminal region of an antibody heavy chain that contains at least a portion of the constant region))как перевести в данном контексте ""whether charge at a certain pH would be more discriminating with respect to clearance values" Спасибо! |
| если сеть большая, то ответы в ней искать долго и муторно |
| (суммарный) заряд при определённых значениях pH по большей части будет иметь определяющее значение на величину клиренса |
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будет больше влиять на значения клиренса или будет более селективным, информативным? еще есть такой контекст: Also examined was whether hydrophobicity of certain CDRs would correlate better with clearance rather than the overall CDR sequence hydrophobicity. With these multitude of variables it was determined that a certain combination of these variables would be more "discriminating towards clearance." |
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