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 littlemoor

link 2.08.2015 7:41 
Subject: long contiguous stretches of homozygosity (LCSH) gen.
Здравствуйте! Подскажите, пожалуйста, перевод генетического термина: long contiguous stretches of homozygosity (LCSH).
вот контекст:
Platforms may contain probes designed for copy‘ number detection only, or may also include probes capable of both copy number detection and allele differentiation, and the majority of platforms available allow for this distinction. Platforms capable of allele differentiation add an additional benefit of detection of absence of heterozygosity (AOH, also called long contiguous stretches of homozygosity (LCSH), loss of heterozygosity (LOH) or regions of homozygosity (ROH)). Due to population substructure, some absence of heterozygosity may be expected. However, a long stretch of homozygosity on a chromosome can indicate uniparental disomy (UPD) either of the whole chromosome or segmental UPD. With crossing over, a long stretch of homozygosity is likely to exist on a chromosome with UPD, even if the UPD is primarily heterodisomy rather than isodisomy
Заранее признательна за помощь!

 second opinion

link 2.08.2015 8:18 
Участки гомозиготности короткой и средней длины встречаются повсеместно, и их количество увеличивается по мере удаления от западной Африки, что является косвенным доказательством волн древнего расселения народов.

 

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