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Subject: to ablate adipogenic activity biol. Mutating both amino acids 1 and 6 to alanine resulted in an unexpected increase in adipogenic activity relative to the KSEVSK peptide in the transdifferentiation assay (assay 1), but these modifications "ablated adipogenic activity" in the pre-adipocyte assay (assay 2).The results of truncating the KSEVSK (SEQ ID NO: 3) peptide to pentamer peptides and the alanine substitution experiments show that the substitution of the flanking lysine residues does not ablate adipogenic activity Ablation of RHAMM expression promotes adipogenesis (Tolg et al., 2006, J Cell Biol). A RHAMM carboxy-terminal sequence dual mutations were necessary in order "to ablate adipogenic activity" of the KSEVSK 6-mer in the pre-adipocyte assay Как корректно перевести "to ablate adipogenic activity" ? Спасибо! |
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я думаю можно перевести как activity ablation = loss of function /потеря функции/ |
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