mechanism in or interfere with the controlled release profile pharm.

[dao2812]

Crisping
The crisping test methods as described herein include methods intended to circumvent the controlled release mechanism in or interfere with the controlled release profile of a pharmaceutical composition. Crisping is a heating process designed to remove, reduce or degrade at least some of the unwanted or undersired excipients and make it easier to abuse the active drug substance. Crisping may be employed to make it easier to crush the composition into small particles/or a powder form so that snorting is made possible or to make it easier to dissolve the composition into an injectable liquid solution or suspension.

Как перевести

The crisping test methods as described herein include methods intended to circumvent the controlled release mechanism in or interfere with the controlled release profile of a pharmaceutical composition

Методы анализа хрупкости, которые описаны в данном документе, влючают методы, предназначенные для того, чтобы "обойти" механизм контролируемого высвобождения ... и дальше вообще непонятно

Речь о возможности злоупотребления ЛС

Спасибо!

[dao2812]

А здесь ввобще финиш:
In certain embodiments, the pharmaceutical compositions of the present invention are not made easier to crush into snortable particles or powder form or to dissolve into an injectable liquid solution by crisping

[glomurka]

какой "хрупкости"? Crisping is a heating process ...
http://www.drugs-forum.com/forum/showthread.php?t=94247

[dao2812]

http://www.proz.com/kudoz/english_to_russian/medical_pharmaceuticals/5759438-crisping_test_methods.html

[dao2812]

что тогда это такое Crisping ?

[glomurka]

написано же Crisping is a heating process designed to remove, reduce or degrade at least some of the unwanted or undersired excipients and make it easier to abuse the active drug substance.
Это процесс, который используют наркоманы для "очистки" действующего вещества из препарата, а не измерение хрупкости в лаборатории.
http://alt.drugs.methadone.narkive.com/lNB9pNLu/crisping-works-with-purdue-pharmas-oxycontin-80-mg-pills

[dao2812]

в данном контексте Crisping, как раз проводят в лаборатории:

Crisping test
Three whole tablets were placed in a 50 ml glass bottle. The bottle was placed in the center of a microwave oven and heated for a predetermined amount of time (e.g. 8 and 16 minutes) at maximum effect (900 W). Afterwards 9 ml of purified water was added to the bottle and the bottle was placed on a flatbed laboratory shaker (IKA-Werke HS-501 digital) and was shook continuously (speed 150/min) for 3 days at ambient temperature to dissolve the tablets and to reduce clumping.

Как тогда перевести?

[dao2812]

Это ж не просто очистка. Есть ли какой-нибудь термин на русском?