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Subject: transcription factor occupancy biol. SR interactions with chromatin are highly dynamic and occur as a rapid and continuous exchange (Hager et al., 2009). Thus, concentrated regions of transcription factor “binding” (as measured by ChIP) actually reflect a shift in the equilibrium towards increased transcription factor occupancy at that region.Спасибо! |
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еще контекст: expression was substantially upregulated by SUMO-deficient KR PR, but not WT PR (Fig. 2C). Additionally, KR PR occupied the MSX2 enhancer 2–3 times more than WT receptor суть в том, что рецепоры садятся на энхансер. но как сказать это по-научному? |
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