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Subject: concepts are a list of genes (что-то новое) biol. Multiple breast cancer “concepts”, as described in the Oncomine database, were associated with the ligand dependent (LD) KR>WT gene signature. According to Oncomine, concepts are derived from gene expression microarrays or gene-copy-number datasets derived from tumor cohorts or cancer cell line experiments.Specifically, concepts are a list of genes from various published datasets that are defined by some criteria (e.g. top 5% of genes expressed in ERBB2-positive breast tumors). These gene signatures were then uploaded into the Oncomine Research Premium Edition (Compendia Bioscience, Ann Arbor, MI) and the database was interrogated for "associated concepts" (reviewed in (Rhodes et al., 2007)). Oncomine concepts are gene lists defined by specific criteria (e.g. top over-expressed genes in a particular tumor cohort). |
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Согласно Oncomine ...(это нечто ) получают из набора данных по анализу экспрессии генов на микроматрицах или количеству копий генов, полученных из экспериментов на "tumor cohorts" или линиях раковых клеток что такое tumor cohorts? связано с когортными исследованиями? |
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здесь http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1877973/ в аннотации объясняется, что входит в понятие "molecular concept". Думаю, надо смотреть синонимы для concept. |
| загвоздить какие-нибудь концепты... |
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Еще контекст The LD 151-gene signature was associated with "multiple breast cancer concepts" with high significance |
| Remarkably, five distinct ERBB2-positive "breast cancer concepts" (two from cell lines and three from tumor cohorts) were independently associated with this LD PR-gene signature |
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