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Subject: hybridization link biol. In one embodiment, a ""hybridization linker"" comprises two nucleic acids that hybridize to form a non-covalent bond. In one embodiment, one of the nucleic acids that forms the ""hybridization link"" can be a region of the aptamer itself and the other nucleic acid can be a nucleic acid that is complementary to that region. Release can be accomplished by any suitable mechanism for disrupting nucleic acid duplexes (while still maintaining compatibility with the assay). In one embodiment, 20 mM NaOH is used to disrupt the ""hybridization linker in the dual catch photocrosslinking assay""Спасибо! |
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