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 fredifredi

link 9.09.2014 13:31 
Subject: "knob and hole" heavy chains what means, please answer gen.
"knob and hole" please answer what means in context of heavy chains

 Shumov

link 9.09.2014 13:40 
The helices of the TPR motives have usually amphipathic character.
Hydrophobic contacts with an aromatic residue phenylalanin from helix
B fitting into a hydrophobic pocket in helix A pack the helices together.
This is also known as “knob and hole” model.

 fredifredi

link 9.09.2014 13:58 
Thank you very much, pleaseq can you ask me how will call this in russian knob and hole
Спасибо, очень.....have a nice day....

 Erdferkel

link 9.09.2014 14:10 
есть
по типу «выступ и впадина» (“knob-and-hole”)
http://www.findpatent.ru/patent/240/2404991.html
но есть и оставленное на англ.
Для BsIgG требуются разработанные "knob and hole" тяжелые цепи для предотвращения образования гетеродимеров
http://www.findpatent.ru/patent/239/2398882.html
второе звучит неуклюже

 

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