soluble endoglin-preventive disorder med.

[Еленаstar]

Пожалуйста, помогите перевести: methods for treating or decreasing the
likelihood of developing a soluble endoglin-preventive disorder in a
subject requiring the administration of a soluble endoglin polypeptide
or a nucleic acid encoding the soluble endoglin polypeptide.
Никак не складывается перевод soluble endoglin-preventive disorder - что за профилактическое заболевание???

Спасибо огромное.

[igisheva]

By "soluble endoglin-preventive disorder" is meant a disorder where a decrease in the soluble endoglin levels (protein or mRNA) or the soluble endoglin biological activity has been detected or implicated in the pathogenesis of the disorder or where specific factors, such as TGF-Я family proteins or TGFP family receptors or events (e.g. fibrosis, angiogenesis, immune activation) that can be inhibited or modulated by soluble endoglin, contribute to the disorder. Non-limiting examples include fibrotic disorders of internal organs and the scarring of skin where TGF-Я is a significant contributor, disorders characterized by excessive angiogenesis (e.g. hemangiomas, pulmonary capillary hemagiomatosis) or abnormal growth of blood vessel such as cancer (e.g., cancer of the breast, prostate, colon, lung, head and neck, liver, kidney, renal system, and endometrium) and inflammatory and immune disorders (e.g. excessive TGF-Я may be related to autoimmune diseases). In one non- limiting example, a subject having a soluble endoglin-preventive disorder may have a decrease (e.g., at least 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or even 100% decrease) in the expression level (e.g., polypeptide or mR A levels) of soluble endoglin or may have a decrease (e.g., at least 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or even 100% decrease) in a biological activity of a soluble endoglin polypeptide as compared to a normal reference as described herein.
Как можно уразуметь из этого абзаца, сабжевое заболевание – это заболевание, обусловленное понижением уровня или биологической активности растворимого эндоглина. Хвори это могут быть самые разные, так что, ПМСМ, тут описательный перевод нужен.