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 molka

link 23.10.2011 10:50 
Subject: D allele of the VEGF gene I/D polymorphism genet.
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Помогите, пожалуйста, разобраться со смыслом предложения:
(The multivariate logistic regres-sion analysis )revealed that the D allele of the VEGF gene I/D polymorphism was an independent risk factor of retinopathy

Контекст:
The distribution of the VEGF DD genotype was significantly different in patients with diabetic retinopathy compared with healthy controls, entire diabetic group and patients with no complications (44 vs. 23, 30 and 21%, respectively; P < 0.01). Such differences were not observed in the diabetic nephro-pathy group. The odds ratio for the D allele was 2.27 (95% CI 1.59–3.25). The multivariate logistic regres-sion analysis revealed that the D allele of the VEGF gene I/D polymorphism was an independent risk factor of retinopathy (P < 0.001). The VEGF þ405 genotype was not associated with diabetic complications in type 2 diabetes patients.

Спасибо!

 moonlight drive

link 23.10.2011 13:08 
just a guess:
В результате проведения многофакторного логистического регрессионного анализа было обнаружено, что аллель D гена VEGF при наличии полиморфизма I/D является независимым фактором риска развития ретинопатии.

 Dimpassy

link 23.10.2011 13:20 
почти: полиморфизм - алелля D, I/D - инсерция/делеция (варианты полиморфизма)

 

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