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idiom. be off beam (VLZ_58); fly off the handle (VLZ_58)
inf. be off one's rocker (Andrey Truhachev); be off your rocker (Andrey Truhachev); have bats in the belfry (Andrey Truhachev); be not right in the head (Andrey Truhachev); be bats (Andrey Truhachev); be batty in the brain (Andrey Truhachev); have a screw loose (Andrey Truhachev); be crazy (Andrey Truhachev); run mad (Andrey Truhachev); go mad (Andrey Truhachev); go crazy (Andrey Truhachev); go bats (Andrey Truhachev); go nuts (Andrey Truhachev); go cuckoo (VLZ_58)
psychol. crack up разг. (Andrey Truhachev); go insane (Andrey Truhachev)