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| have a serious effect on (He was affected by that sting or bite which had such a serious effect on his health causing night-time states of fever. – что серьёзно отразилось на состоянии его здоровья ART Vancouver) | |||
have a serious toll on (отрицательно: It's wonderful that OP had this and other nice experiences. But as someone who has been victimized by homeless people on too many occasions to even keep track of, it doesn't feel great hearing someone doesn't care about my experiences, experiences which have had a serious toll on my mental health, simply because they haven't experienced the same first hand.  reddit.com ART Vancouver) | |||