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в чем дело? stresses
gen.	what is the matter?; what is the trouble?; what is up?; what's the matter?; what's the trouble?; what's up?
в чём дело?
gen.	what's amiss?; what is it all about?; what's the pitch?; why, what's the matter?; what is it?; what in it? (Interex); what is wrong?; what's all this row about?; what's it all about?; what's the story? (4uzhoj); why? (Inna Oslon); what's wrong? (AlexandraM); what is your deal? (Ninwit); what is amiss?; what is the matter?; what is the question?; what’s the matter?; what is this? (xmoffx)
amer.	what's to pay?
cliche.	what's the trouble? (букв.: что вас беспокоит)
idiom.	what is the trouble? (Yeldar Azanbayev)
inf.	Wazap?; what's happening?; what gives? (Interex); what's the big idea?; what's all the ballyhoo about?; what's your problem? (имеет конфликтный оттенок Tion); what's the buzz? (VLZ_58); what's going on? (Alex_Odeychuk); what's up with that? (Roger told me you're moving to Richmond. What's up with that? Don't like it here? ART Vancouver)
Makarov.	whose dog is dead?; what's the row?
mil., lingo	what's the flap? (MichaelBurov)
nonstand.	what is to do?
proverb	what's the matter?
slang	Tsup? (Interex); what's going down?; what the fuck?; what's the scam?; what's up?; what the buzz? (Interex); what in the devil? (Interex); is there something up (hbrhbr); what's the drill (MichaelBurov)
в чём дело
gen.	what is amiss; what is the matter; what is the row
inf.	what gives with (VLZ_58)
В чем дело
gen.	What is (nana_475)

в чём дело: 120 phrases in 12 subjects

American usage, not spelling	4
Animation and animated films	1
Business	1
Cliche / convention	3
Economy	1
General	61
Idiomatic	7
Informal	13
Makarov	24
Mass media	2
Quotes and aphorisms	1
Slang	2