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 snusmumric

link 5.07.2020 21:34 
Subject: relative induction score
Добрый вечер!

Подскажите, пожалуйста, как лучше перевести relative induction score?

Относительный показатель индукции?

Контекст:

Cytochrome P450 induction-mediated drug-drug interaction (DDI) is one of the major concerns in clinical practice and for the pharmaceutical industry. Previously, a novel approach [the relative induction score (RIS)] was developed using the Fa2N-4 immortalized human hepatocyte line and proposed as a tool for predicting magnitude of clinical DDIs caused by induction of CYP3A. The approach is based on combining in vitro induction parameters (EC(50) and E(max)) with the efficacious free plasma concentrations to calculate a relative induction score, which is correlated to the magnitude of clinical DDI for midazolam or ethinyl estradiol.

( https://pubmed.ncbi.nlm.nih.gov/18519654/)

Заранее спасибо.

 

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