preclusion of kidney filtration and favorable antibody serum half-lives pharm.

[dao2812]

FcRn binding and PK parameters

In some embodiments, the antigen-binding constructs of the described herein are
able to bind FcRn. As is known in the art, binding to FcRn recycles endocytosed antibody from the endosome back to the bloodstream. This process, coupled with "preclusion of kidney filtration" due to the large size of the full-length molecule, results in "favorable antibody serum half-lives" ranging from one to three weeks. Binding of Fc to FcRn also plays a key role in antibody transport.

как правильно перевести "preclusion of kidney filtration" и "favorable antibody serum half-lives" в данном контексте

Спасибо большое!