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Subject: mutated to an alanine residue gen. To identify the key amino acids needed for an adipogenic effect, alanine mutagenesis of the KSEVSK 6-mer (SEQ ID NO: 3) was performed. Each amino acid of the KSEVSK 6-mer was "mutated to an alanine residue" to create the following peptides: Peptides in which two residues of the KSEVSK 6-mer were "mutated to alanines" were also synthesized and tested for adipogenic activity Как перевестивыделенные выражения: mutated to an alanine residue или "mutated to alanines" |
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Mutating both amino acids 1 and 6 to alanine resulted in an unexpected increase in adipogenic activity relative to the KSEVSK peptide in the transdifferentiation assay (assay 1), but these modifications ablated adipogenic activity in the pre-adipocyte assay (assay 2). "Mutating both amino acids to alanine" замена с помощью мутации? |
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