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Subject: immune inhibitory molecule biol. Exemplary monoclonal antibodies in clinical use or in development for clinical use for treatment or prevention of infectious disease include, but are not limited to, palivizumab and motavizumab, both of which are specific for respiratory syncitial virus (RSV) glycoprotein F; ibalizumab, an anti-CD4 antibody for blocking human immunodeficiency virus (HIV) entry into host cells; Pro-140 and CCR5mAb004, anti-CCR5 antibodies for blocking HIV entry into host cells; F105, an anti-gp120 antibody for neutralizing envelope glycoprotein gp120 of HIV, which is also used in viral entry; sevirumab, which is specific for cytomegalovirus (CMV) envelope glycoprotein H; bavituximab, an anti-phosphatidyl serine antibody used to neutralize Hepatitis C virus (HCV); nivolumab (also known as MDX1106/BMS936558/ONO-4538) and pidilizumab (also known as CT-011), both of which are specific for the """"immune inhibitory molecule PD-1 on immune cells""" and are used as immunomodulation antibodies in HCV infectionМолекула, ингибирующая имунный ответ? |
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