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Subject: drug loading levels pharm. Compared with the sublingual buprenorphine products on the market, the products of the invention have one or more of the following advantages: ..... 6) Easier dose adjustment, 7) "Ready-to-use" dosage formulation, 8) "high buprenorphine loading"The studies show that even up to at least 35% "BUP loading", the characteristics of the desired liquid crystalline lipid phases are shown when preformulations are added to aqueous buffer Polymeric systems, such as WO2001/154724, have been formulated with up to 20% buprenorphine but there remains scope for precursor formulations with enhanced ""drug loading levels"" |
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