roller mixer pharm.

[dao2812]

Ready-to-administer polymer formulations

The formulations indicated in Table 8 below comprising buprenorphine, polymer and solvent were generated by adding the respective component in the required proportions to a sterile injection glass vial followed by capping with sterile rubber stopper and aluminium crimp cap. Mixing of the formulations (sample sizes 5-10 g) was performed by placing the vials on a "roller mixer" at ambient room temperature until liquid and homogenous formulations were obtained. The formulations were finally sterile filtered through 0.22 m PVDF membrane filters using ca 2.5 bar nitrogen pressure.

Спасибо!