Помогите, пожалуйста: One approach for efficient .... patents.

[Ершова]

Помогите, пожалуйста, перевести предложение. По русски совсем не складывается -
One approach for efficient in vitro or ex vivo Cbl-b attenuation is therefore the prerequisite for increasing the immunoreactivity.
Контекст:
To counteract the risk of an overreaction of the immune system, which can lead to induction of autoimmune reactivity, for example, the inhibition/knockout of Cbl-b functions in T-cells can take place only in a strictly defined period of time. Therefore, it is essential for an adjuvant therapeutic vaccination approach to attenuate Cbl-b in a controlled manner only for a limited period of time to support the development of an immune response specific for a given immunization antigen but to prevent an autoimmune disease by promptly restoring the “normal” immunological state. Therefore, according to the present invention, only a certain selection of isolated cells of the immune system is treated in vitro or ex vivo and then returned to the patient. One approach for efficient in vitro or ex vivo Cbl-b attenuation is therefore the prerequisite for increasing the immunoreactivity.
На предыдущей странице есть следующая информация:
To induce an immune response, essentially two separate signals, independently of one another, are necessary. This mechanism should prevent overshooting of the immune system. The first prerequisite is for the T-cell receptor to also recognize the antigen offered by the APC. If this is not the case, then no further reaction will take place.

Еще раз всем большое спасибо!
Галина Ершова.

[Ankor]

Может быть, примерно так:
Указанный метод in vitro или ex vivo ослабления Cbl-b является необходимым условием увеличения иммунореактивности.

[Ершова]

Спасибо!