Subject: токсикологические данные (алоэ) chem. Плиз хелп перевести следующее:1) Aloeemodin induced tic-mutations in mouse lymphoma L5178-cells and induced micronuclei in a dose-dependent manner in the same cell line. It also inhibited the topoisomerase II-mediated decatenation in mito-chondrial DNA of C fasciculate. Aloeemodin induced DNA damage in the SCGE/Comet-Assay. In a modified Comet-Assay resulted pre-treatment with aloeemodin in a reduced effect of the potent non-intercalating topoisomerase II-inhibitor etoposide, which indicated an inhibition of the interaction of DNA and topoisomerase II by intercalation of aloeemodin. 2) Ames-Test with Salmonella typhi-murium strain TA 1537, TA 1538 and TA 98 without S9 positive; strain TA 1538 with S9 positive; SAL (+/- S9) positive; gene mutations in mammalian cells at HGPRT locus (+/- S9) positive in one experiment, negative in two experiments; chromo-somenaberrations in CHO-cells in vitro (+/- S9) positive (Heidemann 1993). Если не все, то хоть что-нибудь! В частности, кто знает что это: SCGE/Comet-Assay и Ames-Test with Salmonella typhi-murium strain TA 1537 Химики, биологи, не бросайте на растерзание злым заказчикам, поможите! |
Ames-Test with Salmonella typhi-murium strain TA 1537 - Тест Эймса с Salmonella typhimurium, штамм TA 1537. SCGE/Comet-Assay - Гель-электрофорез единичных клеток (метод ДНК-комет) |
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